Valerian may cause drowsiness. Avoid the use of Valerian while driving or operating machinery.
It is recommended to avoid the use of Valerian during pregnancy.
Large doses of Valerian may cause some people to feel depressed, nauseous, headachy, and lethargic; others may find Valerian stimulating rather than sedating.
Use of Valerian with other sedatives may enhance therapeutic properties and possibly adverse effects as well.
Consistent long term use of Valerian is not recommended.
Oral use of St. John’s Wort is generally well-tolerated. Side effects are possible, most commonly insomnia.
The use of St. John’s Wort is not recommended during pregnancy due to its ability to increase muscle tone of the uterus.
The use of St. John’s Wort may reduce the therapeutic effects of the drug digitalis.
St. John’s Wort may interact with various antidepressant medications.
It is recommended to seek professional advice prior to the use of St. John’s Wort in cases of dementia, bipolar disorder, schizophrenia, clinical depression, or if attempting to conceive.